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TCF1 in T cell immunity: a broadened frontier
TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …
downstream of the WNT signalling pathway and are essential for early T cell development …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
Mitochondrial ATP generation is more proteome efficient than glycolysis
Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms,
from yeast to mammals, derive usable energy primarily through glycolysis and respiration …
from yeast to mammals, derive usable energy primarily through glycolysis and respiration …
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells
CRISPR technologies have begun to revolutionize T cell therapies; however, conventional
CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To …
CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To …
[HTML][HTML] A human breast atlas integrating single-cell proteomics and transcriptomics
GK Gray, CMC Li, JM Rosenbluth, LM Selfors… - Developmental cell, 2022 - cell.com
The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …
T cell metabolism in infection
JA Wik, BS Skålhegg - Frontiers in immunology, 2022 - frontiersin.org
T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
[HTML][HTML] Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy
Stem-like CD8+ T cells are regulated by T cell factor 1 (TCF1) and are considered requisite
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …
The cancer metabolic reprogramming and immune response
L ** metabolic reprogramming of cancer and immune cells is a putative
determinant of the antitumor immune response in cancer. Increased evidence suggests that …
determinant of the antitumor immune response in cancer. Increased evidence suggests that …
Protein synthesis, degradation, and energy metabolism in T cell immunity
T cell activation, proliferation, and differentiation into effector and memory states involve
massive remodeling of T cell size and molecular content and create a massive increase in …
massive remodeling of T cell size and molecular content and create a massive increase in …
[HTML][HTML] Proteome turnover in the spotlight: approaches, applications, and perspectives
In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …