The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses

SM Murray, AM Ansari, J Frater, P Klenerman… - Nature Reviews …, 2023 - nature.com
Pre-existing cross-reactive immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …

COVID‐19 in children. II: Pathogenesis, disease spectrum and management

AR Howard‐Jones, DP Burgner… - … of paediatrics and …, 2022 - Wiley Online Library
The global disruption of the COVID‐19 pandemic has impacted the life of every child either
directly or indirectly. This review explores the pathophysiology, immune response, clinical …

SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

CA Cohen, APY Li, A Hachim, DSC Hui… - Nature …, 2021 - nature.com
SARS-CoV-2 infection of children leads to a mild illness and the immunological differences
with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected …

Comparison of seroconversion in children and adults with mild COVID-19

ZQ Toh, J Anderson, N Mazarakis, M Neeland… - JAMA network …, 2022 - jamanetwork.com
Importance The immune response in children with SARS-CoV-2 infection is not well
understood. Objective To compare seroconversion in nonhospitalized children and adults …

[HTML][HTML] Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response

CY Lin, J Wolf, DC Brice, Y Sun, M Locke, S Cherry… - Cell Host & Microbe, 2022 - cell.com
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to
respiratory distress and death. A major unresolved question is whether prior immunity to …

Robust and durable serological response following pediatric SARS-CoV-2 infection

H Renk, A Dulovic, A Seidel, M Becker… - Nature …, 2022 - nature.com
The quality and persistence of children's humoral immune response following SARS-CoV-2
infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 …

Why does the severity of COVID-19 differ with age?: understanding the mechanisms underlying the age gradient in outcome following SARS-CoV-2 infection

P Zimmermann, N Curtis - The Pediatric Infectious Disease …, 2022 - journals.lww.com
Although there are many hypotheses for the age-related difference in the severity of COVID-
19, differences in innate, adaptive and heterologous immunity, together with differences in …

Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

M Vono, A Huttner, S Lemeille, P Martinez-Murillo… - Cell reports, 2021 - cell.com
SARS-CoV-2 infection in children is less severe than it is in adults. We perform a
longitudinal analysis of the early innate responses in children and adults with mild infection …

SARS-CoV-2 infection in children and implications for vaccination

J Nathanielsz, ZQ Toh, LAH Do, K Mulholland… - Pediatric …, 2023 - nature.com
The COVID-19 pandemic caused by novel severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) is responsible for more than 500 million cases worldwide as of April 2022 …

SARS-CoV-2 vaccine induced atypical immune responses in antibody defects: everybody does their best

AF Salinas, EP Mortari, S Terreri, C Quintarelli… - Journal of clinical …, 2021 - Springer
Background Data on immune responses to SARS-CoV-2 in patients with Primary Antibody
Deficiencies (PAD) are limited to infected patients and to heterogeneous cohorts after …