Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination
The licensing step of DNA double-strand break repair by homologous recombination entails
resection of DNA ends to generate a single-stranded DNA template for assembly of the …
resection of DNA ends to generate a single-stranded DNA template for assembly of the …
EXO1 protects BRCA1-deficient cells against toxic DNA lesions
B van de Kooij, A Schreuder, R Pavani, V Garzero… - Molecular Cell, 2024 - cell.com
Inactivating mutations in the BRCA1 and BRCA2 genes impair DNA double-strand break
(DSB) repair by homologous recombination (HR), leading to chromosomal instability and …
(DSB) repair by homologous recombination (HR), leading to chromosomal instability and …
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality
A Khalizieva, SC Moser, P Bouwman… - Genes & …, 2025 - genesdev.cshlp.org
The discovery of BRCA1 and BRCA2 as tumor susceptibility genes and their role in genome
maintenance has transformed our understanding of hereditary breast and ovarian cancer …
maintenance has transformed our understanding of hereditary breast and ovarian cancer …
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease
Maintenance of genome stability is of paramount importance for the survival of an organism.
However, genomic integrity is constantly being challenged by various endogenous and …
However, genomic integrity is constantly being challenged by various endogenous and …
[HTML][HTML] Antioxidant properties of zinc and copper—blood zinc-to copper-ratio as a marker of cancer risk BRCA1 mutation carriers
Pathogenic mutations in BRCA1 (BReast CAncer gene 1) confer high risks of both breast
(up to 70%) and ovarian (up to 40%) cancers. Zinc (Zn) and copper (Cu) are essential for …
(up to 70%) and ovarian (up to 40%) cancers. Zinc (Zn) and copper (Cu) are essential for …
DNA damage-induced proteasome phosphorylation controls substrate recognition and facilitates DNA repair
X Zhang, T Zhu, X Li, H Zhao, S Lin, J Huang… - Proceedings of the …, 2024 - pnas.org
Upon DNA damage, numerous proteins are targeted for ubiquitin-dependent proteasomal
degradation, which is an integral part of the DNA repair program. Although details of the …
degradation, which is an integral part of the DNA repair program. Although details of the …
Brca1 mouse models: functional insights and therapeutic opportunities
Brca1 mouse models were first reported in the mid-1990′ s shortly after cloning the human
gene. Since then, many mouse models with a range of mutations have been generated …
gene. Since then, many mouse models with a range of mutations have been generated …
Blood molybdenum level as a marker of cancer risk on BRCA1 carriers
Abstract Objective To investigate whether Molybdenum blood level is a marker of cancer risk
on BRCA1 carriers. Methods A prospective cohort study was conducted among 989 initially …
on BRCA1 carriers. Methods A prospective cohort study was conducted among 989 initially …
Regulation of pathway choice in DNA repair after Double-strand Breaks
DNA damage signaling is a highly coordinated cellular process which is required for the
removal of DNA lesions. Amongst the different types of DNA damage, double-strand breaks …
removal of DNA lesions. Amongst the different types of DNA damage, double-strand breaks …
Functional Analysis of BARD1 Missense Variants on Homology‐Directed Repair in Ovarian and Breast Cancers
W Li, G Chen, Y Wang, Y Jiang, N Wu… - Molecular …, 2025 - Wiley Online Library
Women with germline BRCA1 mutations face an increased risk of develo** breast and
ovarian cancers. BARD1 (BRCA1 associated RING domain 1) is an essential heterodimeric …
ovarian cancers. BARD1 (BRCA1 associated RING domain 1) is an essential heterodimeric …