Fusions of Cas9 domains and nucleic acid-editing domains
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …
Delivery system for functional nucleases
Abstract Compositions, methods, strategies, kits, and systems for the supercharged protein-
mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are …
mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are …
Nucleobase editors comprising nucleic acid programmable DNA binding proteins
2019-03-13 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
CAS9 variants and uses thereof
Some aspects of this disclosure provide compositions, methods, and kits for improving the
specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants …
specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants …
AAV delivery of nucleobase editors
DR Liu, JM Levy, WH Yeh - US Patent 11,306,324, 2022 - Google Patents
2018-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Cas variants for gene editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …
Switchable Cas9 nucleases and uses thereof
Some aspects of this disclosure provide compositions, methods, systems, and kits for
controlling the activity and/or improving the specificity of RNA-programmable …
controlling the activity and/or improving the specificity of RNA-programmable …
Nuclease profiling system
DR Liu, V Pattanayak - US Patent 10,954,548, 2021 - Google Patents
2016-09-12 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Editing of CCR5 receptor gene to protect against HIV infection
2018-04-06 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Delivery of negatively charged proteins using cationic lipids
2019-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …