Current drug treatment of acute ischemic stroke: challenges and opportunities

DF Muresanu, S Strilciuc, A Stan - CNS drugs, 2019‏ - Springer
Patient-level health outcomes for acute ischemic stroke have significantly improved in the
last decade primarily because of superior overall case management, availability of tailored …

Thrombolytic therapy for wake‐up stroke: A systematic review and meta‐analysis

B Mac Grory, IJ Saldanha, EA Mistry… - European Journal of …, 2021‏ - Wiley Online Library
Background and purpose According to evidence‐based clinical practice guidelines, patients
presenting with disabling stroke symptoms should be treated with intravenous tissue …

Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit

G Furlanis, M Ajčević, A Buoite Stella, T Cillotto… - Journal of …, 2020‏ - Springer
Abstract Backgrounds Wake-Up Stroke (WUS) patients are generally excluded from
thrombolytic therapy (rTPA) due to the unknown time of stroke onset. This study aimed to …

Thrombolysis in Stroke With Unknown Onset Based on Non‐Contrast Computerized Tomography (TRUST CT)

M Sykora, L Kellert, P Michel, A Eskandari… - Journal of the …, 2020‏ - ahajournals.org
Background Intravenous thrombolysis (IVT) in wake‐up stroke (WUS) or stroke with
unknown onset (SUO) has been recently proven to be safe and effective using advanced …

Wake-up stroke: imaging-based diagnosis and recanalization therapy

YL Zhang, JF Zhang, XX Wang, Y Wang… - Journal of …, 2021‏ - Springer
Wake-up stroke (WUS) is a subgroup of ischemic stroke in which patients show no
abnormality before sleep while wake up with neurological deficits. In addition to the …

Wake-up stroke and unknown-onset stroke; occurrence and characteristics from the nationwide Norwegian Stroke Register

MH Søyland, A Tveiten, A Eltoft… - European Stroke …, 2022‏ - journals.sagepub.com
Introduction: Population-based knowledge of the characteristics of wake-up stroke and
unknown-onset stroke is limited. We compared occurrence and characteristics of ischaemic …

Addressing a real‐life problem: treatment with intravenous thrombolysis and mechanical thrombectomy in acute stroke patients with an extended time window beyond …

K Feil, P Reidler, WG Kunz, C Küpper… - European Journal of …, 2020‏ - Wiley Online Library
Background and purpose Acute ischemic stroke treatment with intravenous thrombolysis
(IVT) is restricted to a time window of 4.5 h after known or presumed onset. Recently …

[HTML][HTML] CT-versus MRI-based imaging for thrombolysis and mechanical thrombectomy in ischemic stroke: analysis from the Austrian stroke registry

S Krebs, A Posekany, A Pilz, J Ferrari… - Journal of …, 2022‏ - synapse.koreamed.org
Background and Purpose It is unclear whether a particular stroke imaging modality offers an
advantage for the acute stroke treatment. The aim of this study was to compare procedure …

The efficacy and safety of alteplase treatment in patients with acute ischemic stroke with unknown time of onset:-Real world data

Y Terasawa, R Shimomura, K Sato, T Himeno… - Journal of Clinical …, 2023‏ - Elsevier
Introduction Treatment with alteplase for acute ischemic stroke patients with an unknown
time of onset is safe and effective. However, clinical trials have some selection bias. The …

Thrombolytic Treatment in Wake‐Up Stroke: A Propensity Score–Matched Analysis of Treatment Effectiveness in the Norwegian Stroke Registry

MH Søyland, A Tveiten, A Eltoft… - Journal of the …, 2024‏ - ahajournals.org
Background Previous clinical trials found improved outcome of thrombolytic treatment in
patients with ischemic wake‐up stroke (WUS) selected by advanced imaging techniques …