COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

M Nishiga, DW Wang, Y Han, DB Lewis… - Nature Reviews …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global …

Map** single-cell data to reference atlases by transfer learning

M Lotfollahi, M Naghipourfar, MD Luecken… - Nature …, 2022 - nature.com
Large single-cell atlases are now routinely generated to serve as references for analysis of
smaller-scale studies. Yet learning from reference data is complicated by batch effects …

Cardiac inflammation in COVID-19: Lessons from heart failure

SD Unudurthi, P Luthra, RJC Bose, JR McCarthy… - Life sciences, 2020 - Elsevier
Cardiovascular disease (CVD) is the most common co-morbidity associated with COVID-19
and the fatality rate in COVID-19 patients with CVD is higher compared to other …

Benchmarking atlas-level data integration in single-cell genomics

MD Luecken, M Büttner, K Chaichoompu, A Danese… - Nature …, 2022 - nature.com
Single-cell atlases often include samples that span locations, laboratories and conditions,
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets …

A single-cell RNA expression map of human coronavirus entry factors

M Singh, V Bansal, C Feschotte - Cell reports, 2020 - cell.com
To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-
associated receptors and factors (SCARFs) using single-cell transcriptomics across various …

[HTML][HTML] SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

S Marchiano, TY Hsiang, A Khanna, T Higashi… - Stem cell reports, 2021 - cell.com
COVID-19 patients often develop severe cardiovascular complications, but it remains
unclear if these are caused directly by viral infection or are secondary to a systemic …

Cardiac cell type–specific gene regulatory programs and disease risk association

JD Hocker, OB Poirion, F Zhu, J Buchanan, K Zhang… - Science …, 2021 - science.org
Misregulated gene expression in human hearts can result in cardiovascular diseases that
are leading causes of mortality worldwide. However, the limited information on the genomic …

[HTML][HTML] Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection

FA Robinson, RP Mihealsick… - American Journal …, 2020 - journals.physiology.org
The prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly
reached pandemic proportions, and knowledge about this virus and coronavirus disease …

Mechanics insights of alpha-lipoic acid against cardiovascular diseases during COVID-19 infection

L Rochette, S Ghibu - International Journal of Molecular Sciences, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December
2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global …

Query to reference single-cell integration with transfer learning

M Lotfollahi, M Naghipourfar, MD Luecken, M Khajavi… - bioRxiv, 2020 - biorxiv.org
Large single-cell atlases are now routinely generated with the aim of serving as reference to
analyse future smaller-scale studies. Yet, learning from reference data is complicated by …