Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment
Benzene causes acute myeloid leukemia and probably other hematological malignancies.
As benzene also causes hematotoxicity even in workers exposed to levels below the US …
As benzene also causes hematotoxicity even in workers exposed to levels below the US …
Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk
Advances in laboratory sciences offer much in the challenge to unravel the complex etiology
of cancer and to therefore provide an evidence‐base for prevention. One area where …
of cancer and to therefore provide an evidence‐base for prevention. One area where …
The comparative toxicogenomics database: update 2011
Abstract The Comparative Toxicogenomics Database (CTD) is a public resource that
promotes understanding about the interaction of environmental chemicals with gene …
promotes understanding about the interaction of environmental chemicals with gene …
Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects
Proteochemometric (PCM) modelling is a computational method to model the bioactivity of
multiple ligands against multiple related protein targets simultaneously. Hence it has been …
multiple ligands against multiple related protein targets simultaneously. Hence it has been …
Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research
Background: The suitability for omic analysis of biosamples collected in previous decades
and currently stored in biobanks is unknown. Objectives: We evaluated the influence of …
and currently stored in biobanks is unknown. Objectives: We evaluated the influence of …
[HTML][HTML] t4 report: Supporting read-across using biological data
Read-across, ie filling toxicological data gaps by relating to similar chemicals, for which test
data are available, is usually done based on chemical similarity. Besides structure and …
data are available, is usually done based on chemical similarity. Besides structure and …
Identifying candidate RNA-seq biomarkers for severity discrimination in chemical injuries: A machine learning and molecular dynamics approach
Introduction Biomarkers play a crucial role across various fields by providing insights into
biological responses to interventions. High-throughput gene expression profiling …
biological responses to interventions. High-throughput gene expression profiling …
[BOEK][B] Lu's basic toxicology: fundamentals, target organs, and risk assessment
BM Lee, S Kacew, HS Kim - 2017 - api.taylorfrancis.com
Continuing a long tradition, Lu's Basic Toxicology, Seventh Edition, combines relatively
comprehensive coverage of toxic substances in food, air, and water with brevity, thereby …
comprehensive coverage of toxic substances in food, air, and water with brevity, thereby …
Global gene expression profiling of a population exposed to a range of benzene levels
Background Benzene, an established cause of acute myeloid leukemia (AML), may also
cause one or more lymphoid malignancies in humans. Previously, we identified genes and …
cause one or more lymphoid malignancies in humans. Previously, we identified genes and …
Systems biology in drug discovery and development
EL Berg - Drug discovery today, 2014 - Elsevier
The complexity of human biology makes it challenging to develop safe and effective new
medicines. Systems biology omics-based efforts have led to an explosion of high-throughput …
medicines. Systems biology omics-based efforts have led to an explosion of high-throughput …