Monosaccharide derivatives such as xylose, fucose, N-acetylglucosamine (GlcNAc), N-
acetylgalactosamine (GlaNAc), glucuronic acid, iduronic acid, and N-acetylneuraminic acid …

Glycosaminoglycans (GAG) such as hyaluronan (HA) or chondroitin/dermatan sulfate
(CS/DS) occur in many connective tissues, for instance, in bone, cartilage and skin. Due to …

Multiple cancer therapies nowadays rely on oxidative stress to damage cancer cells. Here
we investigated the biological and molecular effect of oxidative stress on the interaction …

This review summarizes the atomic-resolution structural biology of hyaluronan and its
complexes available in the Protein Data Bank, as well as published studies of atomic …

Presented is an extension of the CHARMM additive all-atom carbohydrate force field to
enable the modeling of phosphate and sulfate linked to carbohydrates. The parameters are …

In this paper, we present the results of molecular dynamics simulations aimed at critical
comparison of classical, biomolecular force fields (FFs) in the context of their capabilities to …

While DNA encodes protein structure, glycans provide a complementary layer of information
to protein function. As a prime example of the significance of glycans, the ability of the cell …

The polydispersity of hyaluronan (HA) presents challenges for analyzing its solution
properties, such as the relationship between mass and particle size. The broad mass range …

Hyaluronan is a polyanionic, megadalton-scale polysaccharide, which initiates cell signaling
by interacting with several receptor proteins including CD44 involved in cell-cell interactions …

Specific sugar residues and their linkages form the basis of molecular recognition for
interactions of glycoproteins with other biomolecules. Seemingly small changes, like the …