Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β-catenin signaling activation
M Katoh - International journal of molecular medicine, 2018 - spandidos-publications.com
β-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …
Rac1, a potential target for tumor therapy
J Liang, L Oyang, S Rao, Y Han, X Luo, P Yi… - Frontiers in …, 2021 - frontiersin.org
RAS-related C3 botulinum toxin substrate 1 (Rac. 1) is one of the important members of Rho
GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell …
GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell …
RAC1 takes the lead in solid tumors
P De, JC Aske, N Dey - Cells, 2019 - mdpi.com
Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular
functions during embryonic development, both in healthy cells and in disease conditions like …
functions during embryonic development, both in healthy cells and in disease conditions like …
Rac1 signaling: from intestinal homeostasis to colorectal cancer metastasis
L Kotelevets, E Chastre - Cancers, 2020 - mdpi.com
The small GTPase Rac1 has been implicated in a variety of dynamic cell biological
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …
Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
RG Morgan, E Mortensson, AC Williams - British journal of cancer, 2018 - nature.com
Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49) potentiates
canonical Wnt/β-catenin signalling and is a marker of normal stem cells in several tissues …
canonical Wnt/β-catenin signalling and is a marker of normal stem cells in several tissues …
Recent advances in Lgr5+ stem cell research
The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both
a marker of adult stem cells and a critical modulator of their activity via its role as an effector …
a marker of adult stem cells and a critical modulator of their activity via its role as an effector …
Molecular features and gene expression signature of metastatic colorectal cancer
M Poturnajova, T Furielova, S Balintova… - Oncology …, 2021 - spandidos-publications.com
Uncontrollable metastatic outgrowth process is the leading cause of mortality worldwide,
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …
The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling
The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …
Compartmentalisation of RAC1 signalling
A Payapilly, A Malliri - Current opinion in cell biology, 2018 - Elsevier
RAC1 signalling has been implicated in a variety of dynamic cell biological processes that
are orchestrated through regulated localisation and activation of RAC1. As a small GTPase …
are orchestrated through regulated localisation and activation of RAC1. As a small GTPase …
Role of IQGAP1 in Carcinogenesis
Simple Summary IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a signal
scaffolding protein that regulates a range of cellular activities by facilitating signal …
scaffolding protein that regulates a range of cellular activities by facilitating signal …