Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …

The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs
within the local chromatin context. The mechanisms by which TFs navigate the nuclear …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

Glucocorticoids remain the frontline treatment for inflammatory disorders, yet represent a
double-edged sword with beneficial therapeutic actions alongside adverse effects, mainly in …

Successful co** with stressful events involves adaptive and cognitive processes in the
brain that make the individual more resilient to similar stressors in the future. Stressful events …

The clinical use of classical glucocorticoids (GC) is narrowed by the many side effects it
causes and the resistance to GC observed in some diseases. Since the great majority of GC …

The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA
and assembles co-regulator complexes to regulate gene transcription. GR agonists are …