Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading
to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found …

Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical
and economic burdens worldwide. Wnt signaling pathways play an important role in …

Aldehyde dehydrogenase 2 (ALDH2) has both dehydrogenase and esterase activity; its
dehydrogenase activity is closely related to the metabolism of aldehydes produced under …

Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying
acetaldehyde and endogenous lipid aldehydes; previous studies suggest a protective role of …

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

The inability of the adult mammalian heart to regenerate represents a fundamental barrier in
heart failure management. By contrast, the neonatal heart retains a transient regenerative …

ABSTRACT Introduction: Aldehyde dehydrogenase-2 (ALDH2) is a main contributor of the
alcohol elimination process. Functional polymorphism in the ALDH2 gene and its inactive …