Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure.
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …

As an emerging discipline, panvascular diseases are a set of vascular diseases with
atherosclerosis as the common pathogenic hallmark, which mostly affect vital organs like the …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca 2+ and
Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the …

Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …

Systemic sclerosis (SSc) is a heterogeneous disease characterized by autoimmunity,
vasculopathy, and fibrosis which affects the skin and internal organs. One key aspect of SSc …

Our laboratory is focused on investigating the supportive role of P53 towards the
maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome …

Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease
characterized by increased pulmonary vascular resistance because of vascular remodeling …

Senescence refers to a cellular state marked by irreversible cell cycle arrest and the
secretion of pro-inflammatory and tissue-remodeling factors. The senescence associated …

Objective Because mitochondrial dysfunction is a key factor in the progression of pulmonary
hypertension, this study tested the hypothesis that transplantation of exogenous viable …

Mitochondrial fission and a Warburg phenotype of increased cellular glycolysis are involved
in the pathogenesis of pulmonary hypertension (PH). The purpose of this study was to …