FGFs, in a complex with their receptors (FGFRs) and heparan sulfate (HS), are responsible
for a range of cellular functions, from embryogenesis to metabolism. Both germ line and …

To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an
extensive PRS online repository for 35 common cancer traits integrating freely available …

Extensive epidemiological studies have demonstrated that there are associations between
variants in intron 2 of FGFR2 and the breast cancer risk in various populations; however, the …

Abstract “BRCAX” refers breast cancers occurring in women with a family history predictive
of being a BRCA1/2 mutation carrier, but BRCA1/2 genetic screening has failed to find …

With the completion of the Human Genome Project and the development of high throughput
technologies, such as next-generation sequencing, the use of multiplex genetic testing, in …

Understanding breast cancer genetic risk relies on identifying causal variants and candidate
target genes in risk loci identified by genome-wide association studies (GWAS), which …

Background Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene (ESR1)
play critical roles in breast cancer (BC) susceptibility. Genome-wide association studies …

Genome-wide association studies (GWAS) explore the genetic causes of complex diseases.
However, classical approaches ignore the biological context of the genetic variants and …

The specific mechanism by which low-risk genetic variants confer breast cancer risk is
currently unclear, with contradictory evidence on the role of single nucleotide …

The associations of SNPs in TOX3 gene with breast cancer risk were investigated by some
Genome-wide association studies and epidemiological studies, but the study results were …