Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence

SZ Alshawwa, AA Kassem, RM Farid, SK Mostafa… - Pharmaceutics, 2022 - mdpi.com
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

Drug delivery to the posterior segment of the eye: biopharmaceutic and pharmacokinetic considerations

R Varela-Fernández, V Díaz-Tomé… - Pharmaceutics, 2020 - mdpi.com
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases
(AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the …

[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery

EM Del Amo, AK Rimpelä, E Heikkinen, OK Kari… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

lncRNA H19 prevents endothelial–mesenchymal transition in diabetic retinopathy

AA Thomas, S Biswas, B Feng, S Chen, J Gonder… - Diabetologia, 2019 - Springer
Aims/hypothesis The pathophysiology of diabetic retinopathy is linked to hyperglycaemia
and its effect on retinal microvascular tissues. The resulting endothelial injury changes the …

Proteomic biomarkers of retinal inflammation in diabetic retinopathy

H Youngblood, R Robinson, A Sharma… - International journal of …, 2019 - mdpi.com
Diabetic retinopathy (DR), a sight-threatening neurovasculopathy, is the leading cause of
irreversible blindness in the developed world. DR arises as the result of prolonged …

Pharmacokinetics of intravitreal anti-VEGF drugs in age-related macular degeneration

L García-Quintanilla, A Luaces-Rodríguez… - Pharmaceutics, 2019 - mdpi.com
Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has
become the standard treatment for Age-Related Macular Degeneration; however, the …

Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

[HTML][HTML] Angiogenic factors and cytokines in diabetic retinopathy

SF Abcouwer - Journal of clinical & cellular immunology, 2013 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) is a sight-threatening complication of both type-1 and type-2
diabetes. The recent success of treatments inhibiting the function of vascular endothelial …

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications …

V Agrahari, PA Burnouf, T Burnouf… - Advanced Drug Delivery …, 2019 - Elsevier
Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …

Proliferative vitreoretinopathy after eye injuries: an overexpression of growth factors and cytokines leading to a retinal keloid

F Morescalchi, S Duse, E Gambicorti… - Mediators of …, 2013 - Wiley Online Library
Eye injury is a significant disabling worldwide health problem. Proliferative Vitreoretinopathy
(PVR) is a common complication that develops in up to 40–60% of patients with an open …