A little over 50 years ago, Sydney Brenner had the foresight to develop the nematode (round
worm) Caenorhabditis elegans as a genetic model for understanding questions of …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

The quantal release of glutamate depends on its transport into synaptic vesicles. Recent
work has shown that a protein previously implicated in the uptake of inorganic phosphate …

Recent efforts in neuroscience research have been aimed at obtaining detailed anatomical
neuronal wiring maps as well as information on how neurons in these networks engage in …

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system.
Synaptic vesicles are loaded with neurotransmitter by means of specific vesicular …

Glutamate-gated chloride channels (GluCls) are found only in protostome invertebrate phyla
but are closely related to mammalian glycine receptors. They have a number of roles in …

We describe an electrophysiological preparation of the neuromuscular junction of the
nematode C. elegans, which adds to its considerable genetic and genomic resources …

The macrocyclic lactones are the biggest selling and arguably most effective anthelmintics
currently available. They are good substrates for the P-glycoproteins, which might explain …

A current challenge in neuroscience is to bridge the gaps between genes, proteins, neurons,
neural circuits, and behavior in a single animal model. The nematode Caenorhabditis …

C. elegans feeding depends on the action of the pharynx, a neuromuscular pump that joins
the mouth to the intestine. The pharyngeal muscle captures food—bacteria—and transports …