Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

This review explores whether fructose consumption might be a contributing factor to the
development of obesity and the accompanying metabolic abnormalities observed in the …

The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue
and centrally in hypothalamic nuclei that regulate body composition. We investigated the …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …

Aims/hypothesis We used oestrogen receptor-α (ERα) knockout (ERKO) and receptor-β
(ERβ) knockout (BERKO) mice to investigate the mechanism (s) behind the effects of …

Numerous peripheral signals contribute to the regulation of food intake and energy
homeostasis. Mechano-and chemoreceptors signaling the presence and energy density of …

Obesity is currently considered as an epidemic in the western world, and it represents a
major risk factor for life-threatening diseases such as heart attack, stroke, diabetes, and …

Adipose tissue performs complex metabolic and endocrine functions. Among the endocrine
products produced by adipose tissue are tumour necrosis factor α, interleukin 6, acylation …