Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

[HTML][HTML] A vessel for change: endothelial dysfunction in cerebral small vessel disease

S Quick, J Moss, RM Rajani, A Williams - Trends in neurosciences, 2021 - cell.com
The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …

Analysis of the mitochondrial membrane potential using the cationic JC-1 dye as a sensitive fluorescent probe

F Sivandzade, A Bhalerao, L Cucullo - Bio-protocol, 2019 - bio-protocol.org
In recent years, fluorescent dyes have been frequently used for monitoring mitochondrial
membrane potential to evaluate mitochondrial viability and function. However, the …

Neurotoxicity of e-cigarettes

JA Ruszkiewicz, Z Zhang, FM Gonçalves… - Food and Chemical …, 2020 - Elsevier
It appears that electronic cigarettes (EC) are a less harmful alternative to conventional
cigarette (CC) smoking, as they generate substantially lower levels of harmful carcinogens …

PDSS2 inhibits the ferroptosis of vascular endothelial cells in atherosclerosis by activating Nrf2

K Yang, H Song, D Yin - Journal of Cardiovascular Pharmacology, 2021 - journals.lww.com
Cardiovascular disease ranks the leading cause of mortality worldwide. Prenyldiphosphate
synthase subunits collectively participate in the formation and development of …

[HTML][HTML] Sex differences in e-cigarette use and related health effects

F Alam, P Silveyra - International Journal of Environmental Research and …, 2023 - mdpi.com
Background: Electronic cigarettes (e-cigarettes) comprise a variety of products designed to
deliver nicotine, flavorings, and other substances. To date, multiple epidemiological and …

Traumatic brain injury and blood–brain barrier (BBB): underlying pathophysiological mechanisms and the influence of cigarette smoking as a premorbid condition

F Sivandzade, F Alqahtani, L Cucullo - International journal of molecular …, 2020 - mdpi.com
Traumatic brain injury (TBI) is among the most pressing global health issues and prevalent
causes of cerebrovascular and neurological disorders all over the world. In addition to the …

[HTML][HTML] A summary of in vitro and in vivo studies evaluating the impact of e-cigarette exposure on living organisms and the environment

A Merecz-Sadowska, P Sitarek… - International Journal of …, 2020 - mdpi.com
Worldwide use of electronic cigarettes has been rapidly expanding over recent years, but
the long-term effect of e-cigarette vapor exposure on human health and environment is not …

Electronic cigarettes induce mitochondrial DNA damage and trigger TLR9 (toll-like receptor 9)-mediated atherosclerosis

J Li, L Huynh, WD Cornwell, MS Tang… - … , and vascular biology, 2021 - ahajournals.org
Objective: Electronic cigarette (e-cig) use has recently been implicated in promoting
atherosclerosis. In this study, we aimed to investigate the mechanism of e-cig exposure …

[HTML][HTML] Cerebrovascular and neurological disorders: protective role of NRF2

F Sivandzade, A Bhalerao, L Cucullo - International journal of molecular …, 2019 - mdpi.com
Cellular defense mechanisms, intracellular signaling, and physiological functions are
regulated by electrophiles and reactive oxygen species (ROS). Recent works strongly …