Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Summary iPSC-based drug discovery led to a phase 1/2a trial of ropinirole in ALS. 20
participants with sporadic ALS received ropinirole or placebo for 24 weeks in the double …

GC-rich tandem repeat expansions (TREs) are often associated with DNA methylation, gene
silencing and folate-sensitive fragile sites, and underlie several congenital and late-onset …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

About 80% of brain disorders have a genetic basis. The pathogenesis of most
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …

In recent years, biomedical research efforts aimed to unravel the mechanisms involved in
motor neuron death that occurs in amyotrophic lateral sclerosis (ALS). While the main …

Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …