Systemic amyloidosis is a rare protein misfolding and deposition disorder leading to
progressive organ failure. There are over 15 types of systemic amyloidosis, each caused by …

Monoclonal Gammopathy of Renal Significance Monoclonal gammopathy of renal
significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for …

Background Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by
deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells …

Daratumumab is a human monoclonal antibody targeting CD38, an antigen uniformly
expressed by plasma cells in multiple myeloma and light-chain amyloidosis (AL). We report …

Amyloid light chain (AL) amyloidosis is among the more common and more severe of the
amyloidoses usually involving the slow proliferation of a bone-marrow-residing plasma cell …

Daratumumab, a monoclonal CD38 antibody, is approved in the treatment of myeloma, but
its efficacy and safety in light-chain (AL) amyloidosis has not been formally studied. This …

Immunoglobulin light chain (AL) amyloidosis is a clonal plasma cell disorder leading to
progressive and life-threatening organ failure. The heart and the kidneys are the most …

Disease overview Immunoglobulin light chain amyloidosis is a clonal, nonproliferative
plasma cell disorder in which fragments of immunoglobulin light or heavy chain are …

Daratumumab has shown promising first results in systemic amyloid light-chain (AL)
amyloidosis. We analyzed a consecutive series of 168 patients with advanced AL receiving …

Venetoclax is efficacious in relapsed/refractory t (11; 14) multiple myeloma, thus warranting
investigation in light-chain amyloidosis (AL). This retrospective cohort includes 43 patients …