Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The metazoan-specific acetyltransferase p300/CBP is involved in activating signal-induced,
enhancer-mediated transcription of cell-type-specific genes. However, the global kinetics …

Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …

Innate immune responses rely on inducible gene expression programmes which, in contrast
to steady-state transcription, are highly dependent on cohesin. Here we address …

Chromosome conformation capture (3C) methods measure the spatial proximity between
DNA elements in the cell nucleus. Many methods have been developed to sample 3C …

It is well known that modifiers play a role in ameliorating or exacerbating disease
phenotypes in patients and carriers of recessively inherited disorders such as sickle cell …

Transcriptional initiation is among the first regulated steps controlling eukaryotic gene
expression. High-throughput profiling of fungal and animal genomes has revealed that RNA …

Metazoan gene transcription by RNA polymerase II (Pol II) is regulated in the promoter-
proximal region. Pol II can undergo termination in the promoter-proximal region but whether …

A longstanding enigma in molecular biology is the lack of scaling of protein-coding genes
with developmental complexity, referred to as the g-value paradox. On the other hand, a …