Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

C Settembre, RM Perera - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Advances in biosensing and environmental monitoring based on electrospun nanofibers

S Kang, K Zhao, DG Yu, X Zheng, C Huang - Advanced Fiber Materials, 2022 - Springer
Electrospun nanofibers (NFs) are directly produced by electrospinning technology. They are
useful in a series of applications such as excellent performance in biosensing and …

Ageing, metabolism and the intestine

MC Funk, J Zhou, M Boutros - EMBO reports, 2020 - embopress.org
The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Kalium channelrhodopsins effectively inhibit neurons

S Ott, S Xu, N Lee, I Hong, J Anns, DD Suresh… - nature …, 2024 - nature.com
The analysis of neural circuits has been revolutionized by optogenetic methods. Light-gated
chloride-conducting anion channelrhodopsins (ACRs)—recently emerged as powerful …

Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit

B Kim, MI Kanai, Y Oh, M Kyung, EK Kim, IH Jang… - Nature, 2021 - nature.com
A balanced intake of macronutrients—protein, carbohydrate and fat—is essential for the well-
being of organisms. An adequate calorific intake but with insufficient protein consumption …

The function and regulation of zinc in the brain

RF Krall, T Tzounopoulos, E Aizenman - Neuroscience, 2021 - Elsevier
Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Intestinal plasticity and metabolism as regulators of organismal energy homeostasis

O Stojanović, I Miguel-Aliaga, M Trajkovski - Nature metabolism, 2022 - nature.com
The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …

Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

SK Kim, DD Tsao, GSB Suh, I Miguel-Aliaga - Cell metabolism, 2021 - cell.com
There has been rapid growth in the use of Drosophila and other invertebrate systems to
dissect mechanisms governing metabolism. New assays and approaches to physiology …

Tryptophan regulates Drosophila zinc stores

E Garay, N Schuth, A Barbanente… - Proceedings of the …, 2022 - pnas.org
Zinc deficiency is commonly attributed to inadequate absorption of the metal. Instead, we
show that body zinc stores in Drosophila melanogaster depend on tryptophan consumption …

Zinc is an important inter-kingdom signal between the host and microbe

P **a, S Lian, Y Wu, L Yan, G Quan, G Zhu - Veterinary Research, 2021 - Springer
Zinc (Zn) is an essential trace element in living organisms and plays a vital role in the
regulation of both microbial virulence and host immune responses. A growing number of …