A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Q Zeng, M Mousa, AS Nadukkandy, L Franssens… - Nature Reviews …, 2023 - nature.com
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

OrthoVenn3: an integrated platform for exploring and visualizing orthologous data across genomes

J Sun, F Lu, Y Luo, L Bie, L Xu, Y Wang - Nucleic acids research, 2023 - academic.oup.com
Advancements in comparative genomics research have led to a growing interest in studying
species evolution and genetic diversity. To facilitate this research, OrthoVenn3 has been …

Complex heatmap visualization

Z Gu - Imeta, 2022 - Wiley Online Library
Heatmap is a widely used statistical visualization method on matrix‐like data to reveal
similar patterns shared by subsets of rows and columns. In the R programming language …

The connectome of an insect brain

M Winding, BD Pedigo, CL Barnes, HG Patsolic, Y Park… - Science, 2023 - science.org
Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

Comparison and evaluation of statistical error models for scRNA-seq

S Choudhary, R Satija - Genome biology, 2022 - Springer
Background Heterogeneity in single-cell RNA-seq (scRNA-seq) data is driven by multiple
sources, including biological variation in cellular state as well as technical variation …

[HTML][HTML] Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer …

P Grivas, AR Khaki, TM Wise-Draper, B French… - Annals of oncology, 2021 - Elsevier
Background Patients with cancer may be at high risk of adverse outcomes from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed a cohort of …

Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis

J Friedman, F Montero, P Bourgois, R Wahbi… - Drug and alcohol …, 2022 - Elsevier
Background Sharp exacerbations of the US overdose crisis are linked to polysubstance use
of synthetic compounds. Xylazine is a veterinary tranquilizer, long noted in the street opioid …

Multivariable association discovery in population-scale meta-omics studies

H Mallick, A Rahnavard, LJ McIver, S Ma… - PLoS computational …, 2021 - journals.plos.org
It is challenging to associate features such as human health outcomes, diet, environmental
conditions, or other metadata to microbial community measurements, due in part to their …

ggVennDiagram: an intuitive, easy-to-use, and highly customizable R package to generate Venn diagram

CH Gao, G Yu, P Cai - Frontiers in Genetics, 2021 - frontiersin.org
Venn diagrams are widely used diagrams to show the set relationships in biomedical
studies. In this study, we developed ggVennDiagram, an R package that could automatically …