Light-sheet fluorescence microscopy has transformed our ability to visualize and
quantitatively measure biological processes rapidly and over long time periods. In this …

Continued advances in precision medicine rely on the widespread sharing of data that relate
human genetic variation to disease. However, data sharing is severely limited by legal …

Introduction Neurofibromatosis 1 and schwannomatosis are characterized by potential
lifelong morbidity and life-threatening complications. To date, however, diagnostic and …

Neuroimaging research requires sophisticated tools for analyzing complex data, but
efficiently leveraging these tools can be a major challenge, especially on large datasets …

Together with the molecular knowledge of genes and proteins, biological images promise to
significantly enhance the scientific understanding of complex cellular systems and to …

Transposable element (TE) insertions are a major source of structural variation in the human
genome. Due to the repetitive nature and biological importance of TEs, many bioinformatic …

Modern scientific and engineering applications increasingly rely on processing large
datasets and executing complex computational workflows on diverse resources. For …

Interpreting genomic variants is critical for diagnosing and assessing the risk of genetic
diseases, particularly rare genetic disorders. Many such conditions are caused by variants …

Next-generation sequencing technologies have generated a massive amount of DNA, RNA,
and protein sequences since their inception. However, data privacy policies often restrict …

A cornerstone of scientific progress is independent data verification. It is, therefore,
necessary to develop robust analysis pipelines that can ensure reproducible and verifiable …