The anterior thalamic nuclei: core components of a tripartite episodic memory system

JP Aggleton, SM O'Mara - Nature Reviews Neuroscience, 2022 - nature.com
Standard models of episodic memory focus on hippocampal–parahippocampal interactions,
with the neocortex supplying sensory information and providing a final repository of …

[HTML][HTML] The anterior thalamic nuclei and cognition: A role beyond space?

AJD Nelson - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
The anterior thalamic nuclei are a vital node within hippocampal-diencephalic-cingulate
circuits that support spatial learning and memory. Reflecting this interconnectivity, the …

[HTML][HTML] Time to retire the serial Papez circuit: Implications for space, memory, and attention

JP Aggleton, AJD Nelson, SM O'Mara - Neuroscience & Biobehavioral …, 2022 - Elsevier
After more than 80 years, Papez serial circuit remains a hugely influential concept, initially
for emotion, but in more recent decades, for memory. Here, we show how this circuit is …

Thalamocortical interactions in cognition and disease: The mediodorsal and anterior thalamic nuclei

BAL Perry, E Lomi, AS Mitchell - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
The mediodorsal thalamus (MD) and anterior thalamic nuclei (ATN) are two adjacent brain
nodes that support our ability to make decisions, learn, update information, form and retrieve …

Construction of complex memories via parallel distributed cortical–subcortical iterative integration

N McNaughton, SD Vann - Trends in neurosciences, 2022 - cell.com
The construction of complex engrams requires hippocampal–cortical interactions. These
include both direct interactions and ones via often-overlooked subcortical loops. Here, we …

Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

LE Mickelsen, WF Flynn, K Springer, L Wilson… - Elife, 2020 - elifesciences.org
The ventral posterior hypothalamus (VPH) is an anatomically complex brain region
implicated in arousal, reproduction, energy balance, and memory processing. However …

Anterior thalamic inputs are required for subiculum spatial coding, with associated consequences for hippocampal spatial memory

BE Frost, SK Martin, M Cafalchio, MN Islam… - Journal of …, 2021 - Soc Neuroscience
Just as hippocampal lesions are principally responsible for “temporal lobe” amnesia, lesions
affecting the anterior thalamic nuclei seem principally responsible for a similar loss of …

Electrophysiological Properties of the Medial Mammillary Bodies across the Sleep–Wake Cycle

CM Dillingham, JJ Wilson, SD Vann - Eneuro, 2024 - eneuro.org
The medial mammillary bodies (MBs) play an important role in the formation of spatial
memories; their dense inputs from hippocampal and brainstem regions makes them well …

[HTML][HTML] Deconstructing the direct reciprocal hippocampal-anterior thalamic pathways for spatial learning

AJD Nelson, L Kinnavane, E Amin… - Journal of …, 2020 - Soc Neuroscience
The hippocampus is essential for normal memory but does not act in isolation. The anterior
thalamic nuclei may represent one vital partner. Using DREADDs, the behavioral …

[HTML][HTML] Time to put the mammillothalamic pathway into context

CM Dillingham, MM Milczarek, JC Perry… - … & Biobehavioral Reviews, 2021 - Elsevier
The medial diencephalon, in particular the mammillary bodies and anterior thalamic nuclei,
has long been linked to memory and amnesia. The mammillary bodies provide a dense …