Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Y Ouyang, J Zhao, S Wang - International Journal of Biological …, 2023‏ - Elsevier
Hydrogel is a three-dimensional network polymer material rich in water. It is widely used in
the biomedical field because of its unique physical and chemical properties and good …

IBD disease-modifying therapies: insights from emerging therapeutics

NG Kotla, Y Rochev - Trends in Molecular Medicine, 2023‏ - cell.com
Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …

Hyaluronic acid in the treatment of dry eye disease

L Hynnekleiv, M Magno… - Acta …, 2022‏ - Wiley Online Library
Dry eye disease (DED) is a highly prevalent and debilitating condition affecting several
hundred million people worldwide. Hyaluronic acid (HA) is a naturally occurring …

Glycosaminoglycan-based hydrogel delivery system regulates the wound microenvironment to rescue chronic wound healing

X Zhang, J Feng, W Feng, B Xu, K Zhang… - … Applied Materials & …, 2022‏ - ACS Publications
Chronic wounds cannot proceed through the normal, orderly, and timely sequence of repair.
The adverse cycle between excess reactive oxide species (ROS) and a persistent …

Hyaluronic acid‐based Bioconjugate systems, Scaffolds, and their therapeutic potential

NG Kotla, IL Mohd Isa, A Larrañaga… - Advanced …, 2023‏ - Wiley Online Library
In recent years, the development of hyaluronic acid or hyaluronan (HA) based scaffolds,
medical devices, bioconjugate systems have expanded into a broad range of research and …

Polysaccharide-based nanocarriers for efficient transvascular drug delivery

M Zhang, H Ma, X Wang, B Yu, H Cong… - Journal of Controlled …, 2023‏ - Elsevier
Polysaccharide-based nanocarriers (PBNs) are the focus of extensive investigation because
of their biocompatibility, low cost, wide availability, and chemical versatility, which allow a …

Natural polymer‐derived bioscaffolds for peripheral nerve regeneration

H Zhang, J Guo, Y Wang, L Shang… - Advanced Functional …, 2022‏ - Wiley Online Library
In recent decades, artificial nerve scaffolds have become a promising substitute for
peripheral nerve repair. Considerable efforts have been devoted to improving the …

A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy

N Wang, Q Zhang, Z Wang, Y Liu, S Yang, X Zhao… - Carbohydrate …, 2024‏ - Elsevier
Triple-negative breast cancer (TNBC) poses a serious threat to women's life and health due
to its high malignancy, strong invasiveness, and propensity for early recurrence and …

A solid–liquid composite lubricating “nano‐snowboard” for long‐acting treatment of osteoarthritis

W Qiu, W Zhao, L Zhang, H Wang, N Li… - Advanced Functional …, 2022‏ - Wiley Online Library
Osteoarthritis is a chronic inflammatory disease characterized by cartilage degeneration.
Anti‐inflammatory therapy has limited effects, and effective reduction of cartilage wear …

A review of hyaluronic acid-based therapeutics for the treatment and management of arthritis

P Walvekar, P Lulinski, P Kumar… - International Journal of …, 2024‏ - Elsevier
Hyaluronic acid (HA), a biodegradable, biocompatible and non-immunogenic therapeutic
polymer is a key component of the cartilage extracellular matrix (ECM) and has been widely …