Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases
K Kulenkampff, AM Wolf Perez, P Sormanni… - Nature Reviews …, 2021 - nature.com
Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology
Microglia are central players in Alzheimer's disease pathology but analyzing microglial
states in human brain samples is challenging due to genetic diversity, postmortem delay and …
states in human brain samples is challenging due to genetic diversity, postmortem delay and …
Super‐resolution infrared imaging of polymorphic amyloid aggregates directly in neurons
Loss of memory during Alzheimer's disease (AD), a fatal neurodegenerative disorder, is
associated with neuronal loss and the aggregation of amyloid proteins into neurotoxic β …
associated with neuronal loss and the aggregation of amyloid proteins into neurotoxic β …
Super-resolving microscopy in neuroscience
Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …
system. The emergence of various super-resolution microscopy methods and specialized …
Cucurbit [7] uril macrocyclic sensors for optical fingerprinting: predicting protein structural changes to identifying disease-specific amyloid assemblies
In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …
pattern of chemical and topological features, which are altered during its misfolding and …
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super …
Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in
Alzheimer's disease (AD) is of great importance for the rational design of preventative …
Alzheimer's disease (AD) is of great importance for the rational design of preventative …
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
E Lobanova, YP Zhang, D Emin, J Brelstaff… - Nature …, 2024 - nature.com
Immunotherapeutic strategies for Alzheimer's and Parkinson's disease would be facilitated
by better measures of inflammation. Here we established an ultra-sensitive single-molecule …
by better measures of inflammation. Here we established an ultra-sensitive single-molecule …
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
The molecular events causing memory loss and neuronal cell death in Alzheimer's disease
(AD) over time are still unknown. Here we found that picomolar concentrations of soluble …
(AD) over time are still unknown. Here we found that picomolar concentrations of soluble …
The influence of pathogenic mutations in α-synuclein on biophysical and structural characteristics of amyloid fibrils
Proteinaceous deposits of α-synuclein amyloid fibrils are a hallmark of human disorders
including Parkinson's disease. The onset of this disease is also associated with five familial …
including Parkinson's disease. The onset of this disease is also associated with five familial …