Cellular and organism survival depends upon the regulation of pH, which is regulated by
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …

The solute carrier family 4 (SLC4) is an important protein responsible for the transport of
various ions across the cell membrane and mediating diverse physiological functions, such …

Background Disturbances in the brain fluid balance can lead to life-threatening elevation in
the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the …

Background The roles of the choroid plexus (CP) and cerebrospinal fluid (CSF) production
have drawn increasing attention in Alzheimer's disease (AD) research. Specifically, studies …

The interoceptive homeostatic mechanism that controls breathing, blood gases and acid‐
base balance in response to changes in CO2/H+ is exquisitely sensitive, with convergent …

Background Differentiating among HCO 3−, CO 3=, and H+ movements across membranes
has long seemed impossible. We now seek to discriminate unambiguously among three …

The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …

The choroid plexus is a tissue located in the lateral ventricles of the brain and is composed
mainly of choroid plexus epithelium cells. The main function is currently thought to be the …

Multiple lines of evidence have shown that lactate-mediated pH alterations in the brains of
patients with neuropsychiatric diseases such as schizophrenia (SCZ), Alzheimer's disease …

Although half of hypertensive patients have hypertensive parents, known hypertension-
related human loci identified by genome-wide analysis explain only 3% of hypertension …