Medical image segmentation is a fundamental and critical step in many image-guided
clinical approaches. Recent success of deep learning-based segmentation methods usually …

Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal
feature of astrocytes is their complex and visually enchanting morphology, referred to as …

To fully understand how the human brain works, knowledge of its structure at high resolution
is needed. Presented here is a computationally intensive reconstruction of the ultrastructure …

Accurate segmentation of objects in microscopy images remains a bottleneck for many
researchers despite the number of tools developed for this purpose. Here, we present …

Cells contain hundreds of organelles and macromolecular assemblies. Obtaining a
complete understanding of their intricate organization requires the nanometre-level, three …

The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

Abstract Knowledge of connectivity in the nervous system is essential to understanding its
function. Here we describe connectomes for both adult sexes of the nematode …

We acquired a rapidly preserved human surgical sample from the temporal lobe of the
cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

An animal's nervous system changes as its body grows from birth to adulthood and its
behaviours mature,,,,,,–. The form and extent of circuit remodelling across the connectome is …