Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

Increasingly, primary hypertension is being considered a syndrome and not a disease, with
the individual causes (diseases) having a common sign—an elevated blood pressure. To …

Aldosterone's role in the kidney and its pathophysiologic actions in hypertension are well
known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other …

Steroid hormones bind receptors in the cell nucleus and in the cell membrane. The most
widely studied class of steroid hormone receptors are the nuclear receptors, named for their …

Aldosterone exerts its best known sodium homeostasis actions by controlling sodium
excretion at the level of the distal tubules via activation of the apical epithelial sodium …

The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and
classically functions as a ligand-dependent transcription factor. It is involved in water …

Corticosteroid receptors in the mammalian brain mediate genomic as well as non-genomic
actions. Although receptors mediating genomic actions were already cloned 35 years ago, it …

Brain mineralocorticoid receptors (MR) mediate effects of glucocorticoid hormones in stress
adaptation, as well as the effects of aldosterone itself in relation to salt homeostasis. Brain …

Striatin-interacting phosphatase and kinase (STRIPAK) complexes are striatin-centered
multicomponent supramolecular structures containing both kinases and phosphatases …

Aldosterone (Aldo) activates both genomic and nongenomic signaling pathways in the
cardiovascular system. Activation of genomic signaling pathways contributes to the adverse …