Although health disparities in women presenting with acute coronary syndrome (ACS) have
received growing attention in recent years, clinical outcomes from ACS are still worse for …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

An initiation-promotion protocol was used to test the hypothesis that unleaded gasoline (UG)
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …

This review summarizes gender differences (GDs) in drug response. Although GDs have
been described both in pharmacodynamics and pharmacokinetics, their role in clinical …

Peripheral artery disease (PAD) has a huge social and economic burden and is an
important contributor to the global health burden. Sex differences in PAD are apparent, with …

ContextMore than 50 million US adults take aspirin regularly for long-term prevention of
cardiovascular disease, typically either 81 mg/d or 325 mg/d. Controversy remains regarding …

Background: Differences in proteomic profiles between men and women may provide
insights into the biological pathways that contribute to known sex differences in …

Patients with diabetes mellitus have an increased prevalence of vascular disease.
Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of …

Biological and sociocultural differences between men and women are complex and likely
account for most of the variations in the epidemiology and treatment outcomes of coronary …

Aspirin is well recognized as an effective antiplatelet drug for secondary prevention in
subjects at high risk of cardiovascular events. However, most patients receiving long-term …