Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …

The management of perioperative bleeding involves multiple assessments and strategies to
ensure appropriate patient care. Initially, it is important to identify those patients with an …

Importance More than 100 million units of blood are collected worldwide each year, yet the
indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to …

1NHS Blood and Transplant, 2Imperial College Healthcare NHS Trust, London, 3University
College Hospitals NHS Trust, London, 4Serious Hazards of Transfusion, NHS Blood and …

Background Limited data suggest that higher hemoglobin thresholds for red-cell
transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants …

Background Fresh red cells may improve outcomes in critically ill patients by enhancing
oxygen delivery while minimizing the risks of toxic effects from cellular changes and the …

Background Some observational studies have reported that transfusion of red-cell units that
have been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse …

Background Randomized, controlled trials have suggested that the transfusion of blood after
prolonged storage does not increase the risk of adverse outcomes among patients, although …

Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …