Advances in pluripotent stem cells: history, mechanisms, technologies, and applications

G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Bioengineering strategies to accelerate stem cell therapeutics

CM Madl, SC Heilshorn, HM Blau - Nature, 2018 - nature.com
Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …

Induced pluripotent stem cells and their use in human models of disease and development

P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Extracellular matrix-derived biomaterials in engineering cell function

H **ng, H Lee, L Luo, TR Kyriakides - Biotechnology advances, 2020 - Elsevier
Extracellular matrix (ECM) derived components are emerging sources for the engineering of
biomaterials that are capable of inducing desirable cell-specific responses. This review …

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

S Musah, A Mammoto, TC Ferrante… - Nature biomedical …, 2017 - nature.com
An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a …

Viscoelastic cell microenvironment: hydrogel‐based strategy for recapitulating dynamic ECM mechanics

Y Ma, T Han, Q Yang, J Wang, B Feng… - Advanced Functional …, 2021 - Wiley Online Library
The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Chemically defined generation of human cardiomyocytes

PW Burridge, E Matsa, P Shukla, ZC Lin, JM Churko… - Nature …, 2014 - nature.com
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …

Adaptable hydrogel networks with reversible linkages for tissue engineering

H Wang, SC Heilshorn - Advanced Materials, 2015 - Wiley Online Library
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …

The extracellular matrix in breast cancer

J Insua-Rodríguez, T Oskarsson - Advanced drug delivery reviews, 2016 - Elsevier
The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

M Nakagawa, Y Taniguchi, S Senda, N Takizawa… - Scientific reports, 2014 - nature.com
In order to apply human embryonic stem cells (hESCs) and induced pluripotent stem cells
(hiPSCs) to regenerative medicine, the cells should be produced under restricted conditions …