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Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy
Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …
Harnessing innate immune pathways for therapeutic advancement in cancer
The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …
Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
BJ Burbach, SD O'Flanagan, Q Shao, KM Young… - Nature …, 2021 - nature.com
Memory CD8+ T cells populate non-lymphoid tissues (NLTs) following pathogen infection,
but little is known about the establishment of endogenous tumor-specific tissue-resident …
but little is known about the establishment of endogenous tumor-specific tissue-resident …
Electroporation and immunotherapy—unleashing the abscopal effect
TF Justesen, A Orhan, H Raskov, C Nolsoe, I Gögenur - Cancers, 2022 - mdpi.com
Simple Summary Electrochemotherapy and irreversible electroporation are primarily used
for treating patients with cutaneous and subcutaneous tumors and pancreatic cancer …
for treating patients with cutaneous and subcutaneous tumors and pancreatic cancer …
Combination of Metal‐Phenolic Network‐Based Immunoactive Nanoparticles and Bipolar Irreversible Electroporation for Effective Cancer Immunotherapy
To circumvent the limitations of conventional cancer immunotherapy, it is critical to prime
antigen‐presenting cells (APCs) to initiate the cancer‐immune cycle. Here, the authors …
antigen‐presenting cells (APCs) to initiate the cancer‐immune cycle. Here, the authors …
Triboelectric immunotherapy using electrostatic-breakdown induced direct-current
H Li, C Chen, Z Wang, Y Huang, G He, Y Liu, P Jiang… - Materials Today, 2023 - Elsevier
Electrical stimulation is a promising technique for drug-free treatment of complex malignant
tumors because it can directly kill tumor cells and induce immunotherapy, avoiding the risk …
tumors because it can directly kill tumor cells and induce immunotherapy, avoiding the risk …
Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique
Cancer immunotherapy is a next-generation treatment strategy; however, its side effects limit
its clinical translation. Here, a novel combination of a multi-functional nano-adjuvant (M-NA) …
its clinical translation. Here, a novel combination of a multi-functional nano-adjuvant (M-NA) …
[HTML][HTML] Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth
Lung cancer is a major contributor to cancer-related death worldwide. siRNA
nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to …
nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to …
Recent trends in STING modulators: Structures, mechanisms, and therapeutic potential
Y Zou, M Zhang, J Zhou - Drug discovery today, 2023 - Elsevier
The cyclic GMP-AMP synthase stimulator (cGAS)–stimulator of interferon gene (STING)
signaling pathway has an integral role in the host immune response through DNA sensing …
signaling pathway has an integral role in the host immune response through DNA sensing …
Intratumoral immunotherapy: is it ready for prime time?
M Ghosn, L Tselikas, S Champiat, F Deschamps… - Current Oncology …, 2023 - Springer
Abstract Purpose of Review This review presents the rationale for intratumoral
immunotherapy, technical considerations and safety. Clinical results from the latest trials are …
immunotherapy, technical considerations and safety. Clinical results from the latest trials are …