Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Cognitive abilities are important predictors of educational and occupational performance,
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …

Understanding normal brain aging and develo** methods to maintain or improve
cognition in older adults are major goals of fundamental and translational neuroscience …

Humans require a plethora of higher cognitive skills to perform executive functions, such as
reasoning, planning, language and social interactions, which are regulated predominantly …

Background Delirium is the most common neuropsychiatric syndrome encountered by
clinicians dealing with older adults and the medically ill and is best characterized by 5 core …

Establishing brain-behavior associations that map brain organization to phenotypic
measures and generalize to novel individuals remains a challenge in neuroimaging …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Over the past decade there has been an enormous rise in the application of functional and
structural connectivity approaches to explore the brain's intrinsic organization in healthy and …

Does the default mode network (DMN) reconfigure to encode information about the
changing environment? This question has proven difficult, because patterns of functional …

Though only a decade has elapsed since the default network (DN) was first defined as a
large‐scale brain system, recent years have brought great insight into the network's adaptive …