[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

The APOBEC protein family: united by structure, divergent in function

JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …

MicroRNA therapeutics: Discovering novel targets and develo** specific therapy

AF Christopher, RP Kaur, G Kaur, A Kaur… - … in clinical research, 2016 - journals.lww.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
in diverse biological process. They act as intracellular mediators that are necessary for …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The biological functions of miRNAs: lessons from in vivo studies

JA Vidigal, A Ventura - Trends in cell biology, 2015 - cell.com
Despite their clear importance as a class of regulatory molecules, pinpointing the relevance
of individual miRNAs has been challenging. Studies querying miRNA functions by …

Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

Epigenetics in cancer

S Sharma, TK Kelly, PA Jones - Carcinogenesis, 2010 - academic.oup.com
Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

[HTML][HTML] MicroRNAs: target recognition and regulatory functions

DP Bartel - cell, 2009 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 23 nt RNAs that play important gene-regulatory
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …

microRNA regulation of inflammatory responses

RM O'Connell, DS Rao… - Annual review of …, 2012 - annualreviews.org
The mammalian inflammatory response is a rapid and complex physiological reaction to
noxious stimuli including microbial pathogens. Although inflammation plays a valuable role …

Physiological and pathological roles for microRNAs in the immune system

RM O'connell, DS Rao, AA Chaudhuri… - Nature Reviews …, 2010 - nature.com
Mammalian microRNAs (miRNAs) have recently been identified as important regulators of
gene expression, and they function by repressing specific target genes at the post …