GAD antibodies in neurological disorders—insights and challenges

F Graus, A Saiz, J Dalmau - Nature Reviews Neurology, 2020‏ - nature.com
Antibodies to glutamic acid decarboxylase (GAD) have been associated with several
neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy …

Book review: GABA and glutamate in the human brain

OAC Petroff - The Neuroscientist, 2002‏ - journals.sagepub.com
Cortical excitability reflects a balance between excitation and inhibition. Glutamate is the
main excitatory and GABA the main inhibitory neurotransmitter in the mammalian cortex …

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

D Huang, Y Wang, JW Thompson, T Yin… - Nature cell …, 2022‏ - nature.com
Many cancers have an unusual dependence on glutamine. However, most previous studies
have focused on the contribution of glutamine to metabolic building blocks and the energy …
AB Rosenberg, CM Roco, RA Muscat, A Kuchina… - Science, 2018‏ - science.org
To facilitate scalable profiling of single cells, we developed split-pool ligation-based
transcriptome sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that …

Two genes encode distinct glutamate decarboxylases

MG Erlander, NJK Tillakaratne, S Feldblum, N Patel… - Neuron, 1991‏ - cell.com
Summary y-Aminobutyric acid (CABA) is the most widely distributed known inhibitory
neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in …

Two forms of the γ‐aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions

DL Kaufman, CR Houser, AJ Tobin - Journal of neurochemistry, 1991‏ - Wiley Online Library
Glutamate decarboxylase (GAD) catalyzes the production of γ‐aminobutyric acid (GABA), a
major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms …

The GABAergic nervous system of Caenorhabditis elegans

SL Mclntire, E Jorgensen, J Kaplan, HR Horvitz - Nature, 1993‏ - nature.com
Abstract γ-AMINOBUTYRIC acid (GABA) is the most abundant inhibitory neurotransmitter in
vertebrates and invertebrates1. GABA receptors are the target of anxiolytic, antiepileptic and …

Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

H Asada, Y Kawamura, K Maruyama, H Kume… - Proceedings of the …, 1997‏ - pnas.org
In addition to its role as an inhibitory neurotransmitter, γ-aminobutyric acid (GABA) is
presumed to be involved in the development and plasticity of the nervous system. GABA is …

Neurobiological mechanisms of the onset of puberty in primates

EI Terasawa, DL Fernandez - Endocrine reviews, 2001‏ - academic.oup.com
An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the
mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the …

Regulation of γ‐aminobutyric acid synthesis in the brain

DL Martin, K Rimvall - Journal of neurochemistry, 1993‏ - Wiley Online Library
γ‐Aminobutyric acid (GABA) is synthesized in brain in at least two compartments, commonly
called the transmitter and metabolic compartments, and because reglatory processes must …