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Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X ** the tumor microenvironment
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …
tumors depend on gene mutation and tumor heterogeneity. The most important …
The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway
H Huang, D Zhang, Y Weng, K Delaney, Z Tang… - Science …, 2021 - science.org
Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular
signaling, in which lysine acetylation and methylation have been the historical focus of …
signaling, in which lysine acetylation and methylation have been the historical focus of …
A role for the Krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation
NC Williams, LAJ O'Neill - Frontiers in immunology, 2018 - frontiersin.org
Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …
[HTML][HTML] AMPK and NRF2: Interactive players in the same team for cellular homeostasis?
E Petsouki, SNS Cabrera, EH Heiss - Free Radical Biology and Medicine, 2022 - Elsevier
NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
Mitochondrial proteome research: the road ahead
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …
[HTML][HTML] Beyond repression of Nrf2: An update on Keap1
Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications
Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …