Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update
K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …
Cytotoxic properties of 1, 3, 4-thiadiazole derivatives—A review
S Janowska, A Paneth, M Wujec - Molecules, 2020 - mdpi.com
During recent years, small molecules containing five-member heterocyclic moieties have
become the subject of considerable growing interest for designing new antitumor agents …
become the subject of considerable growing interest for designing new antitumor agents …
A comparison between observed and DFT calculations on structure of 5-(4-chlorophenyl)-2-amino-1, 3, 4-thiadiazole
The crystal and molecular structure of 5-(4-chlorophenyl)-2-amino-1, 3, 4-thiadiazole 3 was
reported, which was characterized by various spectroscopic techniques (FT-IR, NMR and …
reported, which was characterized by various spectroscopic techniques (FT-IR, NMR and …
Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of α-glucosidase enzyme along with in silico study
Abstract A series of nineteen (1–19) indole-based-thiadiazole derivatives were synthesized,
characterized by 1 HNMR, 13 C NMR, MS, and screened for α-glucosidase inhibition. All …
characterized by 1 HNMR, 13 C NMR, MS, and screened for α-glucosidase inhibition. All …
Thiadiazole inhibitors: a patent review
Introduction: Four isomeric structures of thiadiazole motifs have outstanding
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …
New 1, 3, 4-thiadiazole derivatives with anticancer activity
We designed and synthesized the 1, 3, 4-thiadiazole derivatives differing in the structure of
the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds …
the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds …
Design, synthesis and insecticidal activity of new 1, 3, 4-thiadiazole and 1, 3, 4-thiadiazolo [3, 2-a] pyrimidine derivatives under solvent-free conditions
MF Ismail, HMF Madkour, MS Salem… - Synthetic …, 2021 - Taylor & Francis
(3-Chlorophenyl)-1, 3, 4-thiadiazol-2-amine 2 was synthesized and employed to synthesize
new 1, 3, 4-thiadiazole and 1, 3, 4-thiadiazolo [3, 2-a] pyrimidine derivatives via reactions …
new 1, 3, 4-thiadiazole and 1, 3, 4-thiadiazolo [3, 2-a] pyrimidine derivatives via reactions …
Design, synthesis and in‐vitro evaluation of new furan‐substituted thiadiazolyl hydrazone derivatives as promising antimicrobial agents
Seventeen new furan‐substituted thiadiazolyl hydrazone derivatives bearing 4‐nitrophenyl
moiety were designed, synthesized and tested for their in vitro antimicrobial activity …
moiety were designed, synthesized and tested for their in vitro antimicrobial activity …
Synthesis of novel cytotoxic tetracyclic acridone derivatives and study of their molecular docking, ADMET, QSAR, bioactivity and protein binding properties
Acridone based synthetic and natural products with inherent anticancer activity advancing
the research and generating a large number of structurally diversified compounds. In this …
the research and generating a large number of structurally diversified compounds. In this …
Synthesis, antioxidant and antiproliferative activities of 1, 3, 4-thiadiazoles derived from phenolic acids
K Jakovljević, IZ Matić, T Stanojković… - Bioorganic & medicinal …, 2017 - Elsevier
Abstract Two 2-amino-1, 3, 4-thiadiazoles containing phenolic hydroxyl groups were
combined with different carboxylic acid chlorides giving sixteen amide derivatives with good …
combined with different carboxylic acid chlorides giving sixteen amide derivatives with good …