Recent advances in nanodisc technology for membrane protein studies (2012–2017)
Historically, the main barrier to membrane protein investigations has been the tendency of
membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as …
membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as …
Recent Advances in Real-Time Label-Free Detection of Small Molecules
The detection and analysis of small molecules, typically defined as molecules under 1000
Da, is of growing interest ranging from the development of small-molecule drugs and …
Da, is of growing interest ranging from the development of small-molecule drugs and …
Surface plasmon resonance-based membrane protein-targeted active ingredients recognition strategy: construction and implementation in ligand screening from …
L Chen, D Lv, S Wang, D Wang, X Chen, Y Liu… - Analytical …, 2020 - ACS Publications
Membrane proteins (MPs) are playing important roles in several biological processes.
Screening new candidate compounds targeting MPs is important for drug discovery …
Screening new candidate compounds targeting MPs is important for drug discovery …
Measuring ligand binding kinetics to membrane proteins using virion nano-oscillators
Membrane proteins play vital roles in cellular signaling processes and serve as the most
popular drug targets. A key task in studying cellular functions and develo** drugs is to …
popular drug targets. A key task in studying cellular functions and develo** drugs is to …
Optical imaging of charges with atomically thin molybdenum disulfide
Map** local surface charge distribution is critical to the understanding of various surface
processes and also allows the detection of molecules binding to the surface. We show here …
processes and also allows the detection of molecules binding to the surface. We show here …
Chimeras of KcsA and Kv1 as a bioengineering tool to study voltage-gated potassium channels and their ligands
KS Kudryashova, OV Nekrasova… - Biochemical …, 2021 - Elsevier
Abstract Chimeric potassium channels KcsA-Kv1, which are among the most intensively
studied hybrid membrane proteins to date, were constructed by replacing a part of the pore …
studied hybrid membrane proteins to date, were constructed by replacing a part of the pore …
Label-free multimetric measurement of molecular binding kinetics by electrical modulation of a flexible nanobiolayer
Most label-free techniques rely on measuring refractive index or mass change on the sensor
surface. Thus, it is challenging for them to measure small molecules or enzymatic processes …
surface. Thus, it is challenging for them to measure small molecules or enzymatic processes …
Quantifying ligand–protein binding kinetics with self-assembled nano-oscillators
Measuring ligand–protein interactions is critical for unveiling molecular-scale biological
processes in living systems and for screening drugs. Various detection technologies have …
processes in living systems and for screening drugs. Various detection technologies have …
Virus infection triggers MAVS polymers of distinct molecular weight
The mitochondrial antiviral signaling (MAVS) adaptor protein is a central signaling hub
required for cells to mount an antiviral response following virus sensing by retinoic acid …
required for cells to mount an antiviral response following virus sensing by retinoic acid …
Charge-Sensitive Optical Detection of Small Molecule Binding Kinetics in Normal Ionic Strength Buffer
Most label-free detection technologies detect the masses of molecules, and their sensitivities
thus decrease with molecular weight, making it challenging to detect small molecules. To …
thus decrease with molecular weight, making it challenging to detect small molecules. To …