An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Obesity is a global epidemic, affecting roughly 30% of the world's population and predicted
to rise. This disease results from genetic, behavioral, societal, and environmental factors …

Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity,
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …

Diabetes mellitus (DM) is considered to be a risk factor for dementia including Alzheimer's
disease (AD). However, the molecular mechanism underlying this risk is not well …

Metabolic syndrome is a cluster of cardiovascular risk factors including obesity, diabetes and
dyslipidemia. Insulin resistance (IR) is at the core of metabolic syndrome. In adipose tissue …

Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding
behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early …

Defects in insulin production and signaling are suspected to share a key role in diabetes
and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the …

Neurodegenerative diseases (NDDs) are disorders characterized by progressive
deterioration of brain structure and function. Selective neuronal populations are affected …

Amyloid precursor protein (APP) is a transmembrane precursor protein that is widely
expressed in the central nervous system and peripheral tissues in the liver and pancreas …