Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

CM Guinane, PD Cotter - Therapeutic advances in …, 2013 - journals.sagepub.com
The human gut microbiota has become the subject of extensive research in recent years and
our knowledge of the resident species and their potential functional capacity is rapidly …

Gut microbiome-host interactions in health and disease

JM Kinross, AW Darzi, JK Nicholson - Genome medicine, 2011 - Springer
The gut microbiome is the term given to describe the vast collection of symbiotic
microorganisms in the human gastrointestinal system and their collective interacting …

A review on human fecal metabolomics: Methods, applications and the human fecal metabolome database

N Karu, L Deng, M Slae, AC Guo, T Sajed, H Huynh… - Analytica chimica …, 2018 - Elsevier
Metabolomic analysis of human biospecimens had progressed quickly over the past
decade. Technological and methodological advances have led to the comprehensive …

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

F Hildebrand, TLA Nguyen, B Brinkman, RG Yunta… - Genome biology, 2013 - Springer
Background Murine models are a crucial component of gut microbiome research.
Unfortunately, a multitude of genetic backgrounds and experimental setups, together with …

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

A Scalbert, L Brennan, O Fiehn, T Hankemeier… - Metabolomics, 2009 - Springer
Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …

Metabolomics reveals metabolic biomarkers of Crohn's disease

J Jansson, B Willing, M Lucio, A Fekete, J Dicksved… - PloS one, 2009 - journals.plos.org
The causes and etiology of Crohn's disease (CD) are currently unknown although both host
genetics and environmental factors play a role. Here we used non-targeted metabolic …

[HTML][HTML] APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

TTT Tran, S Corsini, L Kellingray, C Hegarty… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for
Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic …

Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere

F Baquero, VF Lanza, MR Baquero… - Frontiers in …, 2019 - frontiersin.org
Microcins are low-molecular-weight, ribosomally produced, highly stable, bacterial-inhibitory
molecules involved in competitive, and amensalistic interactions between …

Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome

G Le Gall, SO Noor, K Ridgway, L Scovell… - Journal of proteome …, 2011 - ACS Publications
1H NMR spectroscopy of aqueous fecal extracts has been used to investigate differences in
metabolic activity of gut microbiota in patients with ulcerative colitis (UC)(n= 13), irritable …

New developments in Cryptosporidium research

U Ryan, N Hijjawi - International journal for parasitology, 2015 - Elsevier
Cryptosporidium is an enteric parasite that is considered the second greatest cause of
diarrhoea and death in children after rotavirus. Currently, 27 species are recognised as valid …