Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy
Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
Allogeneic natural killer cell therapy
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation
Activation of natural killer (NK) cells with the cytokines interleukin-12 (IL-12), IL-15, and IL-18
induces their differentiation into memory-like (ML) NK cells; however, the underlying …
induces their differentiation into memory-like (ML) NK cells; however, the underlying …
Control of nutrient uptake by IRF4 orchestrates innate immune memory
Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features,
including antigen specificity, clonal expansion and memory. As such, NK cells share many …
including antigen specificity, clonal expansion and memory. As such, NK cells share many …
Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction
T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have
demonstrated impressive activity against relapsed or refractory B-cell cancers yet fail to …
demonstrated impressive activity against relapsed or refractory B-cell cancers yet fail to …
Overcoming tumor resistance mechanisms in CAR-NK cell therapy
A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …
Cytokine-induced memory-like NK cells: from the basics to clinical applications
I Terrén, A Orrantia, G Astarloa-Pando… - Frontiers in …, 2022 - frontiersin.org
Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …
Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer
Numerous studies are exploring the use of cell adoptive therapies to treat hematological
malignancies as well as solid tumors. However, there are numerous factors that dampen the …
malignancies as well as solid tumors. However, there are numerous factors that dampen the …
Cardinal features of immune memory in innate lymphocytes
EK Santosa, JC Sun - Nature immunology, 2023 - nature.com
The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …
Research progress of interleukin-15 in cancer immunotherapy
M Cai, X Huang, X Huang, D Ju, YZ Zhu… - Frontiers in …, 2023 - frontiersin.org
Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is
essential for the development, proliferation, and activation of immune cells, including natural …
essential for the development, proliferation, and activation of immune cells, including natural …