Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …

Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine
stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative …

Although Huntington's disease is a late-manifesting neurodegenerative disorder, both
mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that …

In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb.
One area where neuroblasts that give rise to adult-born neurons are generated is the lateral …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

Selective macroautophagy is an important protective mechanism against diverse cellular
stresses. In contrast to the well-characterized starvation-induced autophagy, the regulation …

Several important advances have been made in our understanding of the pathways that
lead to cell dysfunction and death in Parkinson's disease and Huntington's disease. These …

Huntington disease (HD) is a fatal progressive neurodegenerative disorder caused by an
inherited mutation in the huntingtin (HTT) gene, which encodes mutant HTT protein. Though …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …