In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …

Zika virus (ZIKV) infections are associated with severe neurological complications and are a
global public health concern. There are no approved vaccines or antiviral drugs to inhibit …

Despite the ever-increasing global incidence of dengue fever, there are no specific
chemotherapy regimens for its treatment. Structural studies on dengue virus (DENV) …

Visceral leishmaniasis is a potentially fatal disease caused by infection by the intracellular
protist pathogens Leishmania donovani or Leishmania infantum. Present therapies are …

Trypanothione reductase (TR) is a suitable target for drug discovery approaches against
leishmaniasis, although the identification of potent inhibitors is still challenging. Herein, we …

Around three billion people are at risk of infection by the dengue virus (DENV) and
potentially other flaviviruses. Worldwide outbreaks of DENV, Zika virus (ZIKV), and yellow …

Abstract Dengue, still a “Neglected Tropical Disease” is somehow injustice and remains
uncontrolled globally. World Health Organization (2012–2020) reported that the world's half …

The identification of new viral drugs has become a task of paramount significance due to the
frequent occurrence of viral infections and especially during the current pandemic. Despite …

Direct acting antiviral drugs (DAADs) are becoming therapeutics of choice for the treatment
of viral infections. Successful development of anti HIV and HCV drugs by targeting the viral …

Dengue is a tropical disease caused by the dengue virus (DENV), with an estimate of 300
million new cases every year. Due to the limited vaccine efficiency and absence of effective …