Meiotic recombination: the essence of heredity
N Hunter - Cold Spring Harbor perspectives in biology, 2015 - cshperspectives.cshlp.org
The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …
recombination occurs as a programmed event that culminates in the formation of crossovers …
Homologous recombination in DNA repair and DNA damage tolerance
X Li, WD Heyer - Cell research, 2008 - nature.com
Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …
Meiotic recombination in mammals: localization and regulation
F Baudat, Y Imai, B De Massy - Nature Reviews Genetics, 2013 - nature.com
During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …
exchange of genetic material between homologous chromosomes. These exchanges …
An overview of the molecular mechanisms of recombinational DNA repair
SC Kowalczykowski - Cold Spring Harbor Perspectives …, 2015 - cshperspectives.cshlp.org
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …
genomic integrity. It is a template-directed process that uses a second chromosomal copy …
Mechanism of homologous recombination: mediators and helicases take on regulatory functions
P Sung, H Klein - Nature reviews Molecular cell biology, 2006 - nature.com
Homologous recombination (HR) is an important mechanism for the repair of damaged
chromosomes, for preventing the demise of damaged replication forks, and for several other …
chromosomes, for preventing the demise of damaged replication forks, and for several other …
Gene conversion: mechanisms, evolution and human disease
Gene conversion, one of the two mechanisms of homologous recombination, involves the
unidirectional transfer of genetic material from a'donor'sequence to a highly homologous' …
unidirectional transfer of genetic material from a'donor'sequence to a highly homologous' …
ETAA1 acts at stalled replication forks to maintain genome integrity
The ATR checkpoint kinase coordinates cellular responses to DNA replication stress.
Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only …
Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
New mechanistic and functional insights into DNA topoisomerases
SH Chen, NL Chan, T Hsieh - Annual review of biochemistry, 2013 - annualreviews.org
DNA topoisomerases are nature's tools for resolving the unique problems of DNA
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
RecQ helicases: multifunctional genome caretakers
WK Chu, ID Hickson - Nature Reviews Cancer, 2009 - nature.com
Around 1% of the open reading frames in the human genome encode predicted DNA and
RNA helicases. One highly conserved group of DNA helicases is the RecQ family. Genetic …
RNA helicases. One highly conserved group of DNA helicases is the RecQ family. Genetic …