Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids

PS Auti, G George, AT Paul - RSC advances, 2020 - pubs.rsc.org
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Biologically active quinoline and quinazoline alkaloids part I

XF Shang, SL Morris‐Natschke, YQ Liu… - Medicinal research …, 2018 - Wiley Online Library
Quinoline and quinazoline alkaloids, two important classes of N‐based heterocyclic
compounds, have attracted tremendous attention from researchers worldwide since the 19th …

Asymmetric catalysis mediated by synthetic peptides, version 2.0: expansion of scope and mechanisms

AJ Metrano, AJ Chinn, CR Shugrue, EA Stone… - Chemical …, 2020 - ACS Publications
Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

Peptide-based catalysts reach the outer sphere through remote desymmetrization and atroposelectivity

AJ Metrano, SJ Miller - Accounts of Chemical Research, 2018 - ACS Publications
Conspectus Nature's catalytic machinery has provided endless inspiration for chemists.
While the enzymatic ideal has yet to be fully realized, the field has made tremendous strides …

4 (3H)-Quinazolinone derivatives: Promising antibacterial drug leads

S Gatadi, TV Lakshmi, S Nanduri - European journal of medicinal chemistry, 2019 - Elsevier
Emergence of drug resistance has created unmet medical need for the development of new
classes of antibiotics. Discovery of new antibacterial agents with new mode of action …

Organofluorine chemistry: Promising growth areas and challenges

LV Politanskaya, GA Selivanova… - Russian Chemical …, 2019 - iopscience.iop.org
Currently, the chemistry of organofluorine compounds is a leading and rapidly develo**
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Advances in Palladium‐Catalyzed Decarboxylative Cycloadditions of Cyclic Carbonates, Carbamates and Lactones

Y You, Q Li, YP Zhang, JQ Zhao, ZH Wang… - …, 2022 - Wiley Online Library
Palladium‐catalyzed decarboxylative cycloadditions have emerged as highly effective
methods for constructing structurally diverse carbo‐and heterocycles because of the …

Photo-triggered self-catalyzed fluoroalkylation/cyclization of unactivated alkenes: synthesis of quinazolinones containing the CF 2 R group

J Yang, B Sun, H Ding, PY Huang, XL Tang, RC Shi… - Green …, 2021 - pubs.rsc.org
A novel photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones
containing unactivated alkenes with various fluoroalkyl bromides has been developed. This …

Ruthenium pincer complex catalyzed efficient synthesis of quinoline, 2-styrylquinoline and quinazoline derivatives via acceptorless dehydrogenative coupling …

D Bhattacharyya, P Adhikari, K Deori… - Catalysis Science & …, 2022 - pubs.rsc.org
The synthesis of N-heterocycles has been considered an emerging area of chemical
research due to their extensive utilization in pharmaceuticals, materials science, and natural …

Metal-Free Photoinduced Hydrocyclization of Unactivated Alkenes toward Ring-Fused Quinazolin-4(3H)-ones via Intermolecular Hydrogen Atom Transfer

Z Yang, X Wu, J Zhang, JT Yu, C Pan - Organic Letters, 2023 - ACS Publications
A visible-light-induced hydrocyclization of unactivated alkenes was developed using
3CzClIPN as the photocatalyst to generate substituted α-methyldeoxyvasicinones and α …