The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-
independent long-term potentiation (LTP) in the hippocampus and its function for memory …

Neuronal L-type calcium channels contribute to dendritic excitability and activity-dependent
changes in gene expression that influence synaptic strength. Phosphorylation-mediated …

Although the extracellular matrix plays an important role in regulating use-dependent
synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we …

Memory allows organisms to predict future events based on prior experiences. This requires
encoded information to persist once important predictors are extracted, while also being …

The use of specific activators and inhibitors that penetrate the central nervous system has
suggested an essential functional role of L-type calcium channels (LTCC) in several …

The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …

Cav1. 2 and Cav1. 3 L-type Ca2+ channels (LTCCs) are believed to underlie Ca2+ currents
in brain, pancreatic β cells, and the cardiovascular system. In the CNS, neuronal LTCCs …

Voltage-gated LTCCs (L-type Ca2+ channels) are established drug targets for the treatment
of cardiovascular diseases. LTCCs are also expressed outside the cardiovascular system. In …