Quantifying disease progression in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) exhibits characteristic variability of onset and rate of
disease progression, with inherent clinical heterogeneity making disease quantitation …
disease progression, with inherent clinical heterogeneity making disease quantitation …
Primary lateral sclerosis: a distinct entity or part of the ALS spectrum?
Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …
An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease
Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently
not clinically available for disease diagnosis or analysis of disease progression. If identified …
not clinically available for disease diagnosis or analysis of disease progression. If identified …
[HTML][HTML] miRNA extracted from extracellular vesicles is a robust biomarker of amyotrophic lateral sclerosis
Background and objectives We examined miRNA biomarkers for ALS extracted from
extracellular vesicles in blood samples using a large and diverse patient and control …
extracellular vesicles in blood samples using a large and diverse patient and control …
Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS
Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …
with different progression rates, varying degree of extra-motor involvement and divergent …
Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration
Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …
Imaging cerebral activity in amyotrophic lateral sclerosis
Advances in neuroimaging, complementing histopathological insights, have established a
multi-system involvement of cerebral networks beyond the traditional neuromuscular …
multi-system involvement of cerebral networks beyond the traditional neuromuscular …
Spinal cord imaging in amyotrophic lateral sclerosis: historical concepts—novel techniques
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …
with no effective disease modifying therapies at present. Spinal cord degeneration is a …
Long non-coding and coding RNAs characterization in peripheral blood mononuclear cells and spinal cord from amyotrophic lateral sclerosis patients
S Gagliardi, S Zucca, C Pandini, L Diamanti… - Scientific reports, 2018 - nature.com
Alteration in RNA metabolism, concerning both coding and long non-coding RNAs
(lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis …
(lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis …
Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics
Background Amyotrophic lateral sclerosis (ALS) a highly heterogeneous neurodegenerative
condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed …
condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed …