CD8+ T cell differentiation and dysfunction in cancer
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
TCF1 in T cell immunity: a broadened frontier
TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …
downstream of the WNT signalling pathway and are essential for early T cell development …
Precursor exhausted T cells: key to successful immunotherapy?
Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a
specialized population of CD8+ T cells that exhibit hallmarks of both exhausted and memory …
specialized population of CD8+ T cells that exhibit hallmarks of both exhausted and memory …
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this
Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the …
Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the …
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance
have proven highly effective in cancers with high tumor mutation burden (TMB)(for example …
have proven highly effective in cancers with high tumor mutation burden (TMB)(for example …
[HTML][HTML] Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation
DP Ferreira, JG Silva, T Wyss, SAF Marraco… - Immunity, 2020 - cell.com
Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …
Expansible residence decentralizes immune homeostasis
In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …
development, occupy discrete locations and typically remain fixed in size. The adult immune …