Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has
numerous biomedical applications. Bismuth-based compounds are used extensively as …
numerous biomedical applications. Bismuth-based compounds are used extensively as …
Nickel impact on human health: An intrinsic disorder perspective
The interplay of the presence of nickel and protein disorder in processes affecting human
health is the focus of the present review. Many systems involving nickel as either a cofactor …
health is the focus of the present review. Many systems involving nickel as either a cofactor …
Current and potential applications of bismuth-based drugs
Bismuth compounds have been used extensively as medicines and in particular for the
treatment of gastrointestinal ailments. In addition to bismuth's well known gastroprotective …
treatment of gastrointestinal ailments. In addition to bismuth's well known gastroprotective …
Recent advances in bioinorganic chemistry of bismuth
Bismuth has been used in medicine for over two centuries for the treatment of various
diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity …
diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity …
Future Perspective for Potential Helicobacter Pylori Eradication Therapies
A Debraekeleer, H Remaut - Future microbiology, 2018 - Taylor & Francis
Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …
Peptide–bismuth bicycles: in situ access to stable constrained peptides with superior bioactivity
Constrained peptides are promising next‐generation therapeutics. We report here a
fundamentally new strategy for the facile generation of bicyclic peptides using linear …
fundamentally new strategy for the facile generation of bicyclic peptides using linear …
Coordinating properties of peptides containing histidyl residues
Numerous studies have demonstrated the high metal binding capacity and selectivity of
peptide molecules. The terminal amino group, deprotonated amide nitrogens, and various …
peptide molecules. The terminal amino group, deprotonated amide nitrogens, and various …
Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens
S Salillas, J Sancho - International Journal of Molecular Sciences, 2020 - mdpi.com
Flavodoxins are small soluble electron transfer proteins widely present in bacteria and
absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some …
absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some …
Specific metal ion binding sites in unstructured regions of proteins
In this review, we summarize the most recent observations on some very effective binding
sites (eg ATCUN motif, poly-His, poly-Cys, or Met-containing sequences) for biologically …
sites (eg ATCUN motif, poly-His, poly-Cys, or Met-containing sequences) for biologically …
Nickel metallomics: general themes guiding nickel homeostasis
The nickel metallome describes the distribution and speciation of nickel within the cells of
organisms that utilize this element. This distribution is a consequence of nickel homeostasis …
organisms that utilize this element. This distribution is a consequence of nickel homeostasis …