Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles

DM Griffith, H Li, MV Werrett, PC Andrews… - Chemical Society …, 2021 - pubs.rsc.org
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has
numerous biomedical applications. Bismuth-based compounds are used extensively as …

Nickel impact on human health: An intrinsic disorder perspective

B Zambelli, VN Uversky, S Ciurli - … et Biophysica Acta (BBA)-Proteins and …, 2016 - Elsevier
The interplay of the presence of nickel and protein disorder in processes affecting human
health is the focus of the present review. Many systems involving nickel as either a cofactor …

Current and potential applications of bismuth-based drugs

DM Keogan, DM Griffith - Molecules, 2014 - mdpi.com
Bismuth compounds have been used extensively as medicines and in particular for the
treatment of gastrointestinal ailments. In addition to bismuth's well known gastroprotective …

Recent advances in bioinorganic chemistry of bismuth

H Li, H Sun - Current opinion in chemical biology, 2012 - Elsevier
Bismuth has been used in medicine for over two centuries for the treatment of various
diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity …

Future Perspective for Potential Helicobacter Pylori Eradication Therapies

A Debraekeleer, H Remaut - Future microbiology, 2018 - Taylor & Francis
Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …

Peptide–bismuth bicycles: in situ access to stable constrained peptides with superior bioactivity

S Voss, J Rademann, C Nitsche - … Chemie International Edition, 2022 - Wiley Online Library
Constrained peptides are promising next‐generation therapeutics. We report here a
fundamentally new strategy for the facile generation of bicyclic peptides using linear …

Coordinating properties of peptides containing histidyl residues

I Sóvágó, K Várnagy, N Lihi, Á Grenács - Coordination Chemistry Reviews, 2016 - Elsevier
Numerous studies have demonstrated the high metal binding capacity and selectivity of
peptide molecules. The terminal amino group, deprotonated amide nitrogens, and various …

Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens

S Salillas, J Sancho - International Journal of Molecular Sciences, 2020 - mdpi.com
Flavodoxins are small soluble electron transfer proteins widely present in bacteria and
absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some …

Specific metal ion binding sites in unstructured regions of proteins

H Kozlowski, S Potocki, M Remelli… - Coordination Chemistry …, 2013 - Elsevier
In this review, we summarize the most recent observations on some very effective binding
sites (eg ATCUN motif, poly-His, poly-Cys, or Met-containing sequences) for biologically …

Nickel metallomics: general themes guiding nickel homeostasis

AM Sydor, DB Zamble - Metallomics and the Cell, 2013 - Springer
The nickel metallome describes the distribution and speciation of nickel within the cells of
organisms that utilize this element. This distribution is a consequence of nickel homeostasis …